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Roberta Attanasio
Assoc Professor
Ph.D. Microbiology University of Rome "La Sapienza", Italy 1987
Research Areas:
Molecular Genetics/Cell Physiology
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Research Description:
Untitled Document
The cells of the immune system work together as an exceptionally coordinated team
to control the many external and internal factors that lead to development of
disease. As we change and adapt to new circumstances using our accumulated experiences,
so does the immune system. Many characteristics of each single cell, the type
of cell-to-cell communication and the level of coordination among the various
cells continually change, resulting in the reshaping of the team's organization
and efforts. In our laboratory, we design and carry out research projects with
the goal of understanding how the immune system adapts and responds to changes
caused by infections, vaccine administrations, and increasing age. Our model systems
consist of mice and nonhuman primates, including macaques and baboons, as well
as antigens derived from Mycobacterium tuberculosis and the human immunodeficiency
virus. By using animals that belong to all age groups, we assess how increasing
age correlates with the reshaping of the immune response and, therefore, with
different responses to vaccines. Using nonhuman primate models, we also carry
out studies designed to understand how the immunoglobulin gene pool evolves within
a species.
Recent Publications:
Rogers KA, Richardson JP, Scinicariello F, Attanasio R. Molecular Characterization of IgD in Mammals: Immunoglobulin Heavy Constant Delta (IGHD) Genes in Dogs, Chimpanzees and Four Old World Monkey Species. Immunology, in press.
Scinicariello F, Masseoud F, Jayshankar L, Attanasio R. Sooty mangabey (Cercocebus torquatus atys) IGHG and IGHA genes. Immunogenetics, in press.
Scinicariello, F., Engleman, C.N., Jayashankar, L., McClure, H.M., Attanasio, R. (2004). Rhesus macaque
antibody molecules: sequences and heterogeneity of alpha and gamma constant regions. Immunol. 111(1):66-74.
Rogers, K.A., Scinicariello, F., Attanasio, R. (2004). Identification and characterization of macaque CD89
(immunoglobulin A Fc receptor). Immunol. 113(2):178-86.
Jayashankar, L., Brasky, K.M., Ward, J.A., Attanasio, R. (2003). Lymphocyte modulation in a baboon model of immunosenescence.Clin Diagn Lab Immunol. 10(5):870-5.
See more publications >>
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