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The Murphy Lab

Publications 

  • Loyd, D.R., Morgan M.M. and Murphy, A.Z. Sexually dimorphic activation of the periaqueductal gray – rostral ventromedial medullary circuit during the development of morphine tolerance in the rat. European J. Neurosci. , 27 (2008) 1517. pdf

  • Normandin, J.J. and Murphy, A.Z. Nucleus paragigantocellularis afferents in male and female rats: organization, gonadal steroid sensitivity and activation during sexual behavior. Journal Comp Neurol, in press.
  • LaPrairie, J. and Murphy, A.Z.  Long-term consequences of neonatal pain are exacerbated in females.  Pain, 132 (2007) S120-9. pdf
  • Greenspan, J.D., Craft, R.M., LeResche, L., Arendt-Nielsen, L., Berkley, K.J., Fillingim, R.B., Gold, M.S.,  Holdcroft, A., Lautenbacher, S., Mayer, E.A., Mogil, J.S., Murphy, A.Z. , Traub, R.J., the Consensus Working Group of the Sex, Gender, and Pain SIG of the IASP. Studying sex and gender differences in pain and analgesia: A consensus report. Pain, 132 (2007) S26-S45. pdf

  • Loyd, D.R., Morgan, M.M. and Murphy, A.Z.  Morphine preferentially activates the Periaqueductal Gray – Rostral Ventromedial Medullary pathway in the male rat. Neuroscience, 147 (2007) 456-68. pdf

    Ji, Y., A.Z. Murphy, and R.J. Traub. Estrogen modulation of morphine analgesia of visceral pain in female rats is supraspinally and peripherally mediated.  J. Pain, 8 (2007) 494-502. pdf

  • Cutler, S.M., VanLandingham, J.W., Murphy, A.Z., and D.G. Stein.  Slow-release and injected progesterone treatments enhance acute recovery after traumatic brain injury. Pharmacology, Biochem. & Behavior 200684(3):420-8. pdf

  • Salierno J.D., Snyder N.S., Murphy A.Z., Poli M., Hall S., Baden D., Kane A.S.  Harmful algal bloom toxins alter c-Fos protein expression in the brain of killifish, Fundulus heteroclitus.  Aquat Toxicol. 78 (2006) 350-7. pdf

  • Ji, Y., A.Z. Murphy, and R.J. Traub. Sex Differences in Morphine Induced Analgesia of Visceral Pain are Surpspinally and Peripherally Mediated. Am J Physiol Regul Integr Comp Physiol. 291(2006) R307-14.pdf

  • Wang, X., R.J. Traub and A.Z. Murphy  Systemic morphine produces a greater degree of analgesia in male versus female rats in a model of persistent pain. Am J Physiol Regul Integr Comp Physiol. 291(2006):R300-6. pdf

  • Marson L. and A.Z. Murphy. Identification of neural circuits involved in female sexual response: a dual virus and anterograde tracing study. Am J Physiol Regul Integr Comp Physiol. 291(2006) R419-28. pdf

  • Loyd, D. and A.Z. Murphy Sex differences in the anatomical and functional organization of the midbrain periaqueductal gray-rostral ventromedial medullary pathway: A potential circuit mediating the sexually dimorphic actions of morphine.  J. Comp. Neurol. 496 (2006) 723-38. pdf

  • Young, L.J., Murphy Young, A.Z. and L. Hammock.  Neuroanatomy of the pair bond.  J. Comp. Neurol. 493(2005) 51-7. pdf

  • Robertson, C.L., Puskar, A., Hoffman, G.E., Murphy, A.Z., Saraswati, M., and Fiskum, G.  Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell death after traumatic brain injury  in female rats.  Experimental Neurology  197(2006)235-43.

  • Lim, M.M., Murphy, A.Z., and Young, L.J.  Ventral striatopallidal oxytocin and vasopressin V1a receptors in the monogamous prairie vole (Microtus ochrogaster). J. Comp. Neurol. 468 (2004) 555-570.

  • Cushing, B.S., Murphy, A.Z., Le, W.W., Hoffman, G.E. The making of a monogamous male: The role of steroid receptors. Hormones and Behavior (2004).

  • Hoffman, G.E., Moore, N., Fiskum, G., and A.Z. Murphy.  Ovarian steroid modulation of seizure severity and hippocampal neuronal damage induced by kainic acid administration. Experimental Neurol. 171(2001) 272-84.

  • Ji, Y., Murphy, A.Z. and R.J. Traub. Estrogen modulates the visceromotor reflex and responses of spinal dorsal horn neurons to colorectal stimulation in the rat. J. Neurosci. 23 (2003) 3908-3915.

  • Traub, R.J. and Murphy, A.Z. Colonic inflammation induces Fos in the thoracolumbar spinal cord and preferentially activates spino-parabrachial neurons. Pain, 95 (2002) 93-102.

  • Le, W.-W., Wise, P.M., Murphy, A.Z. and G.E. Hoffman. Parallel declines in Fos activation of the medial anteroventral periventricular (AVPV) nucleus and LHRH neurons in middle-aged rats. Endocrinology, 142 (2001) 4976-4982.

  • Hoffman, G.E., A.Z. Murphy, W.W. Le and C.L. Koski. Divergent effects of ovarian steroids on experimental allergic encephalitis.  Experimental Neurology; 171(2001):272-84.

  • Murphy, A.Z. and Hoffman, G.E.  Distribution of gonadal steroid receptor containing neurons in the preoptic-periaqueductal gray-brainstem pathway: A unique circuit for the initiation and maintenance of male reproductive behavior. J. Comp. Neurol., 438 (2001) 191-212.

  • Ren K., Wei1 F., Dubner R., Murphy A.Z., Hoffman G.E. Progesterone attenuates persistent inflammatory hyperalgesia in female rats: involvement of spinal NMDA receptor mechanisms. Brain Res. 2000 (865) 272-277.

  • Murphy, A.Z. and Hoffman, G.E.  Distribution of androgen and estrogen receptor containing neurons in the male rat periaqueductal gray.  Horm. Beh., 36 (1999) 98-108.

  • Murphy, A.Z., Rizvi, T.A., Ennis, M., and Shipley, M.T.  The organization of preoptic-medullary circuits in the male rat: evidence for interconnectivity of neural structures involved in reproductive behavior, antinociception and cardiovascular regulation.  Neurosci., 91 (1999)1103-1116.

  • Rizvi, T.A., Murphy, A.Z., Ennis, M., Behbehani, M.M. and Shipley, M.T.  Expression of c-fos in rat pontine tegmental neurons following electrical stimulation of the medial preoptic area.  Brain Res., 789 (1998) 256-262.

  • Rizvi, T.A., Murphy, A.Z., Ennis, M., Behbehani, M.M. and Shipley, M.T.  Medial preoptic-induced fos expression in the periaqueductal gray overlaps with medial preoptic terminals and medullary output neurons:  A new approach for simultaneous anatomical and functional mapping of excitatory neural circuits. J. Neurosci., 16 (1996) 333-344.

  • Murphy, A.Z., Ennis, M., Shipley, M. and Behbehani, M.M.  Fos expression induced by changes in arterial pressure is localized in distinct, longitudinally organized columns of neurons in the rat midbrain periaqueductal gray.  J. Comp. Neurol., 360 (1995) 286-300.

  • Murphy, A.Z., Ennis, M., Shipley, M. and Behbehani, M.M.  Directionally-specific changes in arterial pressure induce differential patterns of Fos expression in discrete areas of the rat brainstem: A double labeling study for Fos and catecholamines.  J. Comp. Neurol., 349 (1994) 36-50.

  • Zemlan, F.P., Murphy, A.Z. and Behbehani, M.M.  Effect of 5-HT1A agonists, serotonin and raphe stimulation on spinal dorsal horn nociceptive neurons in the rat.  Pharmacology, 48 (1994) 1-10.

  • Murphy, A.Z. and Behbehani, M.M.  Role of norepinephrine in the interaction between the lateral reticular nucleus and the nucleus raphe magnus:  An electrophysiological and behavioral study.  Pain, 55 (1993) 183-193.

  • Murphy, A.Z. and Behbehani, M.M.  Electrophysiological characterization of the projection from the nucleus raphe magnus to the lateral reticular nucleus:  Possible role of an excitatory amino acid in synaptic activation.  Brain Res., 606 (1993) 68-78.

  • Murphy, A.Z., Murphy, R.M. and Zemlan, F.P.  Role of spinal serotonin1 receptor subtypes in thermally and mechanically elicited nociceptive reflexes.  Psychopharm., 108 (1992) 123-130.